Male infertility can have various genetic causes that can affect sperm production, sperm motility, and sperm morphology.
Some of the common genetic causes of male infertility are:
1. Klinefelter syndrome
It is a genetic disease in which a male possesses an extra X chromosome (XXY) in addition to his normal XY chromosome.
2. Y chromosome microdeletions
Infertility may result from small Y chromosomal deletions that have an impact on the genes involved in sperm production.
3. Cystic fibrosis transmembrane conductance regulator (CFTR) gene mutations
The function of the vas deferens, which carries sperm from the testicles to the urethra, can be impacted by mutations in the CFTR gene.
4. Congenital bilateral absence of the vas deferens (CBAVD)
It is a genetic condition that results in infertility when the vas deferens is absent or underdeveloped.
5. Androgen receptor gene mutations:
This gene's mutations can impact how cells react to testosterone, which can reduce sperm production.
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