IMSI IVF Treatment

Intracytoplasmic Morphologically Selected Sperm Injection -IMSI IVF Treatment is a technique used during IVF to help couples in conceiving.

In this fertility treatment, a single sperm is selected with the help of a high-magnification digital imaging microscope as it enables the doctors to differentiate between the structure of the sperm and exclude the suspected variations. Then the selected sperm is morphologically injected into the egg. 

Why IMSI IVF Treatment Performed?

IMSI is used for men with sizeable abnormal sperm and failed IVF with ICSI treatment. This new and advanced technique increases the possibility of fertilization and normal embryo development.

Why IMSI IVF Treatment Performed?

In the IMSI procedure,

  1. The microscope is used to select the sperm, magnifying it almost 6,000 times.
  2. This helps the doctor to differentiate between normal and abnormal sperm.
  3. The doctor can quickly determine the structure of the sperm and eliminate the sperm that exhibits abnormalities, which is not possible in ICSI treatment.
  4. The technique is beneficial and ensures better results than the traditional method of selecting sperms for fertilisation.

Who is IMSI IVF Treatment Suitable for?

IMSI treatment is recommended for men in the following condition: –

  • Poor sperm motility
  • Low quantity of sperm in the semen sample
  • Surgically recovered sperm
  • Poor sperm morphology
  • The ratio of abnormally shaped sperm is extremely high
  • Have a history of failed ICSI IVF cycles.
  • The age of male is more than 40 years
  • The couple had numerous miscarriages and abortions in the past.

How does IMSI IVF Treatment Work?

IMSI uses a highly effective micro that magnifies the sperm up to 6000 times, which helps the embryologist detect virtually any structural alteration and abnormality that are difficult to detect with traditional techniques. This helps collect high-quality sperm with normal morphology for fertilisation of the egg.

The steps involved in the IMSI procedure are as follows: –

Semen Sample Collection and Preparation

A fresh or frozen semen sample is collected and prepared by the embryologist. And all impurities are removed from it by treating it with a specific solution.

Sperm Selection

Sperm is selected for injection by examining it under a microscope which is more potent than a standard microscope. This helps in the selection of sperm that are of the best quality and healthy.

Egg Selection

Similar to the ICSI procedure, eggs are collected from the female partner in IMSI and cleaned to remove the unwanted particles. The eggs are then analysed under a microscope, and healthy ones are chosen for fertilisation with the sperm.

Sperm Injection

The selected sperm(s) is then put in a fine glass needle and injected into the chosen egg(s) for fertilisation. These fertilised eggs are cultured in a sterile culture petri dish in an incubator.

Embryo Transfer

Once the embryo(s) have been cultured and are ready to be transferred, the female partner will be called to the clinic and have the embryos inserted into her uterus.

After approximately 14 days, a pregnancy test is done to check whether pregnancy has been achieved.

What is Risk involved in IMSI IVF Treatment?

The following are the risks involved in IMSI treatment.

  • A male child born with the help of IMSI treatment is more prone to fertility issues in the future.
  • There are chances of significant congenital disabilities such as Wiedemann syndrome, Angelman syndrome, sex chromosome abnormalities, and hypospadias.
  • It increases the chance of multiple pregnancies because multiple embryos are implanted inside the uterus to increase the chances of pregnancy.
  •  Chances of complications like- early labour, high blood pressure, gestational diabetes, and the need for a c-section.

Success Rate of IMSI IVF Treatment

The success rate of IMSI varies from person to person. However, the success rate is approx. 70 to 80%. The treatment of IMSI involves micro-injecting only morphologically best sperm into an egg. So, its success rate is higher than ICSI.

Treatment Cost of IMSI IVF Treatment in India?

The average treatment cost of IMSI IVF treatment in India is between 1,80,000 to 2,50,000 INR. However, its price increases when ART techniques like IVF are added to IMSI. It is performed using a high digital magnifying lens 6000 times the magnification. It allows the doctor to select high-quality sperm without abnormalities before microinjecting the eggs.

What are the Benefits of IMSI?

The following are the benefits of IMSI IVF treatment: –

  • It doubles the pregnancy rate
  • It lowers the abortion rate by 60%.
  • It reduces the chances of miscarriage.
  • It helps in enhancing fertility and pregnancy rates.


Today there are various sophisticated technologies available that offer great news for couples struggling to conceive, and IMSI is one such. This increases the chance of successful pregnancy. So, visit the fertility clinic who have experienced doctors and make your dream true of having a child.

Frequently Asked Questions (FAQs)

The IMSI IVF treatment is recommended for men who have: –

  • A high percentage of abnormally shaped sperm.
  • Previous history of failed ICSI – IVF cycle.
  • The low number of sperm
  • Surgically recovered sperm

The IMSI IVF treatment is recommended for women who have:

  • History of failed IVF cycle.
  • History of miscarriage and repeated abortions.
  • No implantation in the standard quality of the egg.
  • The Blastocyte stage is made of rare embryos.

IMSI is expensive and time-consuming because, in this treatment procedure, sperms are examined closely before fertilisation using a high digital magnifying lens which is 6000 times the magnification.

IMSI is an additional step in the ICSI process. It is a test performed on a semen sample and is a non-invasive treatment. The risk associated with IMSI is the same as ICSI. However, it does not carry any additional known risks for the person undergoing fertility treatment

Yes, IMSI is better than ICSI because the chance of having a live birth with IMSI is 32%, whereas, in ICSI, it is 25%. It also lowers the risk of miscarriage and increases the pregnancy rate compared to ICSI.

Before microinjecting, doctors perform IMSI to differentiate between normal sperms and abnormal sperms. It is performed using a high-powered microscope with 6000 times digital imaging. This helps in analysing the ultrastructure of the sperm.

An IVF cycle usually takes around six weeks, although this is dependent on each individual and often governed by menstrual cycles. Usually, using IMSI does not impact this timeline.

: IVF with IMSI is only offered to those for whom it is considered relevant. This includes those women who have had earlier failed implantation or miscarriage.

One can use donated eggs or sperm in IVF with IMSI.

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